Mesothelioma Treatment Option: Comprehensive Guide :

Hello readers,
In this journal article, we will provide an in-depth guide on the various treatments available for mesothelioma, a rare and aggressive form of cancer caused by exposure to asbestos. Mesothelioma is known for its poor prognosis, but with the right treatment approach, patients can prolong their lifespan and improve their quality of life. We hope that through this guide, patients, their families, and caregivers can make informed decisions about mesothelioma treatment options.

What is Mesothelioma?

Mesothelioma is a type of cancer that affects the lining of the lungs, abdomen, or heart. It is caused by exposure to asbestos, a naturally occurring mineral that was widely used in industrial and commercial products before its harmful effects were discovered. Mesothelioma is a rare disease, with only about 3,000 cases diagnosed each year in the United States.

Types of Mesothelioma

There are three main types of mesothelioma, each affecting different parts of the body. They include:

  • Pleural mesothelioma, which affects the lining of the lungs
  • Peritoneal mesothelioma, which affects the lining of the abdomen
  • Pericardial mesothelioma, which affects the lining of the heart

Stages of Mesothelioma

Mesothelioma is also staged based on the extent of the cancer. The stages range from I to IV, with IV being the most advanced. The stages are determined by factors such as the size and location of the tumor, whether it has spread to other parts of the body, and if the cancer has metastasized.

Mesothelioma Treatment Options

Treatment for mesothelioma depends on factors such as the stage of the cancer, location of the tumor, and overall health of the patient. Treatment options include:

  1. Surgery
  2. Chemotherapy
  3. Radiation Therapy
  4. Targeted Therapy
  5. Immunotherapy
  6. Multimodal Therapy

Surgery for Mesothelioma

Surgery is often used to remove mesothelioma tumors and surrounding tissue. The type of surgery used depends on the location and stage of the cancer. Common surgical procedures used for mesothelioma include:

  • Extrapleural pneumonectomy (EPP), which involves removing the lung, pleura, diaphragm, and pericardium
  • Pleurectomy with decortication (P/D), which involves removing the affected pleura and other tissues, but leaving the lung intact
  • Peritonectomy, which involves removing the affected peritoneum and other tissues

Chemotherapy for Mesothelioma

Chemotherapy involves the use of drugs to kill cancer cells. Chemotherapy can be administered orally or intravenously and can be used alone or in combination with other treatments. Common chemotherapy drugs used for mesothelioma include:

  • Cisplatin
  • Carboplatin
  • Alimta (pemetrexed)
  • Gemcitabine
  • Onconase

Radiation Therapy for Mesothelioma

Radiation therapy uses high-energy radiation to kill cancer cells. Radiation therapy can be used before or after surgery or as a standalone treatment. Common radiation therapy techniques used for mesothelioma include:

  • External beam radiation therapy
  • Intensity-modulated radiation therapy (IMRT)
  • Brachytherapy

Targeted Therapy for Mesothelioma

Targeted therapy is a type of treatment that targets specific molecules or proteins that are involved in the growth and spread of cancer cells. Common targeted therapy drugs used for mesothelioma include:

  • Bevacizumab
  • Atezolizumab
  • Crizotinib
  • Imatinib

Immunotherapy for Mesothelioma

Immunotherapy works by boosting the body’s immune system to attack cancer cells. Common immunotherapy drugs used for mesothelioma include:

  • Pembrolizumab
  • Nivolumab
  • Ipilimumab
  • Interleukin-2

Multimodal Therapy for Mesothelioma

Multimodal therapy involves using a combination of treatments, such as surgery, chemotherapy, and radiation therapy, to treat mesothelioma. This approach is usually used for patients with advanced mesothelioma or those who are not candidates for surgery.


Q: What are the symptoms of mesothelioma?

A: Symptoms of mesothelioma can vary depending on the type and stage of the cancer. Common symptoms of pleural mesothelioma include chest pain, shortness of breath, coughing, and fatigue. Common symptoms of peritoneal mesothelioma include abdominal pain, swelling, and digestive issues. Pericardial mesothelioma is rare but can cause chest pain and difficulty breathing.

Q: Who is at risk for developing mesothelioma?

A: People who have been exposed to asbestos are at the highest risk of developing mesothelioma. This includes people who worked in industries such as construction, shipbuilding, and manufacturing.

Q: Is mesothelioma curable?

A: Unfortunately, there is currently no cure for mesothelioma. However, with early detection and treatment, patients can prolong their lifespan and improve their quality of life.

Q: What are the side effects of mesothelioma treatment?

A: The side effects of mesothelioma treatment can vary depending on the type of treatment used. Common side effects of chemotherapy include nausea, vomiting, hair loss, and fatigue. Common side effects of radiation therapy include skin irritation, fatigue, and nausea.

Q: Are there any clinical trials for mesothelioma treatments?

A: Yes, there are ongoing clinical trials for mesothelioma treatments. Patients may be eligible to participate in these trials if they meet certain criteria.


Mesothelioma is a rare and aggressive form of cancer that requires specialized treatment. This guide has provided an overview of the various treatment options available, including surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy, and multimodal therapy. Patients with mesothelioma should work closely with their healthcare team to determine the best treatment approach for their specific case. It is also important for patients to seek emotional and psychological support from their loved ones and support groups to manage the impact and challenges of the disease.

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